It could be anything really, and that's what this thread is for. What drives you insane when it comes to games?
Off the top of my head, the major thing that can drive me absolutely batty are QTE's (Quick Time Events). Thanks to the Resident Evil series, I grew to despise QTE's. My reason being is that my reaction time isn't always fast enough, or I could be in a tight spot in the game when a QTE pops up and I impulsively press the wrong button because I'm under pressure. Personally, Resident Evil 4 wasn't so bad with the QTE's. The only times I really died were probably my own fault and were a result of Leon losing his health completely. (Or accidently executing Ashley. lol, major facepalm moment whenever that happened)
Then RE5 rolled around, and it took QTE's to a whole new level. Suddenly, these damn QTE's are my leading causes of death and it was at this time I began to hate those sequences. RE6 makes it worse by far. There's so many of those sequences in the game that I could often find my character getting brutally killed and facing the "Game Over" screen in an instant. Normally I'm pretty accurate with most QTE's though. Should I fail and get killed however, I'll have to do it all over again which gets infuriating. On top of that, any enemy that can straight up kill me outright drives me insane too.
I love the Resident Evil games, I just really hate the QTE's and didn't care for them ever since they were introduced. I'm aware that QTE's exist in other games too, its just that the RE games are the only game's I've really played that feature them.
Anyone care to share stories? I have more stories of course, but if I told them now, I'd be in front of the computer all day.